Using Fick's law, the kinetic model of KGM extraction was established by mass transfer mechanism analysis. KGM extraction in konjac is a very complicated process. From the kinetic model and experimental data analysis, the rate constant is not only related to temperature, but also to medicinal materials. The particles themselves are related and are mainly controlled by internal diffusion. After data fitting, the final model y = A1* exp( - x t 1 ) + y0 conforms to the dynamic equation and the model can describe the extraction process more accurately. Using the Arrhenius equation, the activation energy Ea = 1.996 × 104J mol and the velocity number k0 = 29.3045 were further obtained. It was finally determined that the model can better describe the kinetic equation of the extraction process. This result can be extracted from KGM. The choice of process design and operating conditions provides a theoretical basis.