In order to obtain the best technology of microwave extraction of ferulic acid from Xinjiang, and the in vitro antioxidant activity of crude polysaccharides from Xinjiang, the microwave extraction process of water-soluble polysaccharides from Xinjiang ferulic acid was optimized by response surface methodology, and selected on the basis of single factor experiment. The liquid-to-material ratio, extraction temperature, extraction time and microwave power were designed and tested. The product of the mass of the obtained polysaccharide and the percentage of polysaccharide content measured by phenol sulfuric acid method was used as an optimization index, and the in vitro clearance of Xinjiang ferulic acid polysaccharide was detected. Activity of 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals. Results: The optimum process conditions were liquid to material ratio of 120:1 (mL/g), extraction time of 13 min, extraction temperature of 80 °C, microwave power of 600 W, and the actual yield of polysaccharide was 6.93%, which was close to the theoretical value. Xinjiang ferulic acid polysaccharide has a good scavenging effect on DPPH free radicals. When the concentration is 1 000g/mL, the clearance rate of DPPH free radicals in Xinjiang ferulic root polysaccharide is 91.67%, which is close to the scavenging effect of VC.